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Newest Articles
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Morag K. Mansley, Christian Niklas, Regina Nacken, Kathrin Mandery, Hartmut Glaeser, Martin F. Fromm, Christoph Korbmacher, Marko Bertog
In murine cortical collecting duct cells, prostaglandin E2 (PGE2) stimulates transepithelial sodium transport mediated by the epithelial sodium channel (ENaC). PGE2 is synthesized and secreted by the cells and acts on basolateral prostaglandin E receptor type 4 (EP4).
Article
Tibor G. Szanto, Florina Zakany, Ferenc Papp, Zoltan Varga, Carol J. Deutsch, Gyorgy Panyi
Szanto et al. propose a new gating scheme to explain how the Shaker family of voltage-gated potassium channels are inactivated at negative membrane potentials and how these channels recover from this state.
Article
Kotaro Oyama, Kotaro Oyama, Mizuho Gotoh, Yuji Hosaka, Tomoko G. Oyama, Aya Kubonoya, Yuma Suzuki, Tomomi Arai, Seiichi Tsukamoto, Yuki Kawamura, Hideki Itoh, Seine A. Shintani, Toshiko Yamazawa, Mitsumasa Taguchi, Shin’ichi Ishiwata, Norio Fukuda
Living cells convert the hydrolytic energy of ATP to heat during various biochemical reactions. Oyama et al. show that thermogenesis increases temperature on the order of 1°C only proximal to the heat source, but not on a global basis in either non-excitable or excitable cells.
Article
Brenda Farrell, Benjamin L. Skidmore, Vivek Rajasekharan, William E. Brownell
By comparing the measured displacement charge with a voltage-sensing model, Farrell et al. identify two hyperpolarized states and two reaction pathways in OHCs, suggesting that multiple pathways may allow these cells to amplify acoustic vibrations throughout the audible frequency range of mammals.
Article
Johan E. Larsson, Urban Karlsson, Xiongyu Wu, Sara I. Liin
The anticonvulsant retigabine targets the neuronal M-channel but has adverse clinical effects due to its poor KV7 subtype specificity. Larsson et al. reveal that the selectivity of retigabine is improved by coapplication with the endocannabinoid arachidonoyl-L-serine.
Article
Antonio Suma, Daniele Granata, Andrew S. Thomson, Vincenzo Carnevale, Vincenzo Carnevale, Brad S. Rothberg, Brad S. Rothberg
Polyamines regulate K+ efflux from cells by binding to K channels in a voltage-dependent manner. Suma et al. analyze how two polyamines, spermidine and spermine, bind and block the prokaryotic K channel MthK.
Article
Timothy J. Wilding, James E. Huettner
AMPA and NMDA receptors underlie several neuropathologies, but the detailed gating mechanism of these channels remains incompletely understood. Wilding and Huettner show that exposure to Cd opens AMPA and NMDA receptors with cysteine substitutions near the inner helix bundle-crossing gate.

Related Articles from Rockefeller University Press

Current Issue
Volume 152,
Issue 6,
June 1, 2020
Reviews & Opinions
Commentary
Harley T. Kurata
Kv7 channels are powerfully regulated by a wide variety of physiological and pharmacological signals. Larsson et al. describe the direct modulation of Kv7 channels by endocannabinoids and explore how combinations of Kv7 activators with distinct subtype specificities might lead to effective and selective drug cocktails.
Commentary
Stephen C. Cannon
Calcium gluconate has been empirically administered to hasten recovery of force during an episode of periodic paralysis. By using a genetically engineered mouse model, Uwera and colleagues show that low Ca2+ clearly promotes a loss of force in affected muscle, thereby providing the first evidence for the benefit of maintaining normal Ca2+ levels in this disorder.
Commentary
Crina M. Nimigean
Polyamines can modulate membrane excitability by blocking ion flux through ion channels. Suma et al. determined the location of the binding site for polyamines inside a model potassium channel pore.

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